Can Ashwagandha Cause Depression?

Munira Electricwala

Psychologist | Researcher | Psychological Scientist | Writer

30 Sep 20244 min read

High angle of bowl with powder and leaves - Can Ashwagandha Cause Depression?

Introduction: Ashwagandha - Miracle Herb or Potential Depression Trigger?

Ashwagandha, a popular adaptogenic herb known for its stress-relieving properties, has garnered attention for its potential effects on mental health. But can this ancient remedy cause depression? The relationship between ashwagandha and mood disorders is complex, with varying evidence suggesting both positive and negative effects. Understanding this connection is crucial for anyone considering ashwagandha as a supplement.

Understanding Ashwagandha and Depression by Definition

Ashwagandha, scientifically known as Withania Somnifera, is an Ayurvedic herb traditionally used to promote overall wellness and reduce stress. Often referred to as Indian ginseng or winter cherry, it is celebrated for its adaptogenic properties, helping the body manage stress.

Depression is a mental health disorder characterized by persistent feelings of sadness, hopelessness, and a lack of interest in activities once enjoyed. It can significantly impact daily life, affecting work, relationships, and overall well-being.

Can Ashwagandha Cause Depression?

The answer to whether ashwagandha can cause depression is not straightforward. Research indicates that while some individuals may experience negative effects, many studies highlight the herb's potential benefits for mood enhancement.

Ashwagandha can have mixed effects on depression. While it may help reduce depressive symptoms in some individuals, especially those with schizophrenia, others may experience a worsening of depression due to drops in energy or mood changes. Some users also report feeling emotionally numb or experiencing negative side effects.

Present Research Findings on the Connection Between Ashwagandha and Depression

Studies Suggests Positive Effects: A study (2024) published in the Journal of Integrative and Complementary Medicine found that ashwagandha may help alleviate symptoms of depression due to its active compounds, including withanolides. Another research article (2021) noted that ashwagandha influences serotonin and GABA pathways, which are crucial for mood regulation.

Studies Indicating No Significant Link: Some studies (2019) have shown minimal or no significant changes in depressive symptoms among participants taking ashwagandha compared to placebo groups. This suggests that while it may help some individuals, it does not universally affect everyone positively.

Potential Negative Effects: There are reports of individuals experiencing increased anxiety or mood swings when taking high doses of ashwagandha. These side effects can sometimes lead to confusion about its overall impact on mental health.

Comorbid Conditions: Ashwagandha has been noted to reduce stress and anxiety levels (2023), which are often comorbid with depression. By alleviating these conditions, it may indirectly benefit those suffering from depressive symptoms.

Individual Variability: The effects of ashwagandha can vary widely among individuals based on factors such as dosage, duration of use, and personal health history. Therefore, some may find it beneficial while others could experience adverse effects.

Symptoms of Depression to check. This will help you understand when to seek help:

Emotional Symptoms

Persistent Sadness: A continuous feeling of sadness or emptiness.
⁠Irritability: Increased frustration or anger over minor issues.
Feelings of Hopelessness: A belief that things will never get better.
⁠Guilt or Worthlessness: Excessive feelings of guilt or a sense of being a failure.

Physical Symptoms

Changes in Appetite: Significant weight loss or gain, or changes in eating habits.
Sleep Disturbances: Insomnia or sleeping too much.
Fatigue: A constant feeling of tiredness or lack of energy.
⁠Aches and Pains: Unexplained physical symptoms, such as headaches or digestive issues.

Cognitive Symptoms

⁠Difficulty Concentrating: Trouble focusing, making decisions, or remembering things.
Negative Thinking: A tendency to dwell on negative thoughts or events.

Behavioural Symptoms

⁠Withdrawal from Social Activities: Avoiding friends, family, and previously enjoyed activities.
⁠Decreased Performance: A decline in work or academic performance.

Mave Health offers personalized support programs and resources on tDCS designed to address these complex issues.

Do Read More About Depression

Conclusion

The relationship between ashwagandha and depression is intricate and varies from person to person. While many studies suggest that this adaptogenic herb can positively influence mood by reducing stress and anxiety, there are instances where it may not be suitable for everyone. As with any supplement, it's crucial to consult with a healthcare provider before starting ashwagandha, especially if you have pre-existing mental health conditions or are taking other medications. Personalised healthcare decisions are vital in navigating the complexities of mental health.

References

Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021). Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology, 6(1), 20. https://doi.org/10.3390/jfmk6010020
Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine, 98(37), e17186. https://doi.org/10.1097/md.0000000000017186
Majeed, M., Nagabhushanam, K., Murali, A., Vishwanathan, D. T., Mamidala, R. V., & Mundkur, L. (2024). A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of Integrative and Complementary Medicine, 30(5), 459–468. https://doi.org/10.1089/jicm.2023.0279
Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
Pedersen, T. (2023a, August 31). Can Ashwagandha Trigger Anxiety? Healthline. https://www.healthline.com/health/anxiety/can-ashwagandha-cause-anxiety
Rd, J. K. M. (2023, November 7). Health Benefits of Ashwagandha, Based on Research. Healthline. https://www.healthline.com/nutrition/ashwagandha
Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468–1495. https://doi.org/10.2174/1570159x19666210712151556
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