Can Lack Of Vitamin D Cause Depression?

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Munira Electricwala
Psychologist | Researcher | Psychological Scientist | Writer
2 Oct 20244 min read
Girl having healthy breakfast but Vitamin D Deficiency Leave her Feel Down in the Dumps

Introduction: Can a Vitamin D Deficiency Leave You Feeling Down in the Dumps?

The connection between vitamin D deficiency and depression has garnered significant attention in recent years. Vitamin D, often referred to as the "sunshine vitamin," is crucial for various bodily functions, including bone health and immune system regulation. However, emerging research suggests that it may also play a role in mental health. This article explores the complex relationship between vitamin D deficiency and depression, highlighting both supporting and opposing evidence.

Understanding Vitamin D and Depression by Definition

Vitamin D: Vitamin D is a fat-soluble vitamin that helps the body absorb calcium, promotes bone health, and supports immune function. It can be obtained through sunlight exposure, certain foods, and supplements.

Depression: Depression is a mood disorder characterised by persistent feelings of sadness, hopelessness, and a lack of interest in previously enjoyed activities. 

Can Lack of Vitamin D Cause Depression?

Research findings are mixed. Some studies suggest that low levels of vitamin D are associated with an increased risk of depression, while others find no significant correlation.

Present Research Findings on the Connection Between Lack of Vitamin D and Depression

Studies Suggests:

  • A systematic review (2018) indicated that low vitamin D levels are correlated with depressive symptoms, particularly in older adults.
  • Research in Pakistan (2018) found that individuals with severe vitamin D deficiency exhibited higher rates of depression, especially among older adults.
  • Another study (2022) noted that vitamin D supplementation improved depressive symptoms in some individuals.
  • A large-scale study involving over 18,000 participants found no significant difference in depression scores between those taking vitamin D supplements and those receiving a placebo.
  • Observational studies (2010) have shown that while many people with depression have low vitamin D levels, the reverse causality—whereby depression leads to lower sunlight exposure—cannot be ruled out.

Mixed Evidence:

  • Some reviews (2008) highlight that while there is a biological plausibility for the association—due to vitamin D's role in brain function—evidence remains inconsistent across different populations. 

Potential Mechanisms:

  • Vitamin D may influence mood through its effects on serotonin production and neuroplasticity. The presence of vitamin D receptors in the brain suggests it may play a role in regulating mood disorders.

Cultural and Environmental Factors:

Symptoms of Depression to check. This will help you understand when to seek help:

Emotional Symptoms

Physical Symptoms

Cognitive Symptoms

Behavioural Symptoms 

It is essential for individuals experiencing symptoms of depression to consult healthcare providers for personalized guidance. If you or someone you know is struggling with depression, consider reaching out for professional help. Mave Health offers tailored support and resources for tDCS to help individuals navigate their mental health challenges effectively.

Do Read More About Depression
  1. Supporting a Loved One with Depression: Practical Tips
  2. Foods for Depression: What to Eat and What to Avoid
  3. How Meditation Can Help with Depression?
  4. tDCS Device for Depression Treatment

Conclusion

The relationship between vitamin D deficiency and depression is complex and multifaceted. While some studies indicate a potential link, others do not find significant evidence to support this connection. Individual factors such as age, lifestyle, and geographical location may influence these outcomes. In summary, while there is some evidence suggesting that lack of vitamin D may contribute to depressive symptoms, further research is needed to clarify this relationship and determine effective interventions.

References

  1. Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013). Vitamin D deficiency and depression in adults: systematic review and meta-analysis. The British Journal of Psychiatry, 202(2), 100–107. https://doi.org/10.1192/bjp.bp.111.106666
  2. Buell, J. S., & Dawson-Hughes, B. (2008). Vitamin D and neurocognitive dysfunction: Preventing “D”ecline? Molecular Aspects of Medicine, 29(6), 415–422. https://doi.org/10.1016/j.mam.2008.05.001
  3. De Souza De Santana, K. V., Oliver, S. L., Mendes, M. M., Lanham-New, S., Charlton, K. E., & Ribeiro, H. (2022). Association between vitamin D status and lifestyle factors in Brazilian women: Implications of Sun Exposure Levels, Diet, and Health. EClinicalMedicine, 47, 101400. https://doi.org/10.1016/j.eclinm.2022.101400
  4. G, R., & Gupta, A. (2014). Vitamin D Deficiency in India: Prevalence, Causalities and Interventions. Nutrients, 6(2), 729–775. https://doi.org/10.3390/nu6020729
  5. Khan, B., Shafiq, H., Abbas, S., Jabeen, S., Khan, S. A., Afsar, T., Almajwal, A., Alruwaili, N. W., Al-Disi, D., Alenezi, S., Parveen, Z., & Razak, S. (2022). Vitamin D status and its correlation to depression. Annals of General Psychiatry, 21(1). https://doi.org/10.1186/s12991-022-00406-1
  6. Ld, S. S. M. R. (2022, January 12). Is a Vitamin D Deficiency Causing Your Depression? Healthline. https://www.healthline.com/nutrition/depression-and-vitamin-d
  7. Lennon, A. (2022, August 18). Vitamin D supplementation may help reduce depressive symptoms, study finds. Medical News Today. Retrieved September 17, 2024, from https://www.medicalnewstoday.com/articles/vitamin-d-supplementation-seems-to-alleviate-depressive-symptoms-in-adults
  8. Musazadeh, V., Keramati, M., Ghalichi, F., Kavyani, Z., Ghoreishi, Z., Alras, K. A., Albadawi, N., Salem, A., Albadawi, M. I., Salem, R., Abu-Zaid, A., Zarezadeh, M., & Mekary, R. A. (2023). Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses. Pharmacological Research, 187, 106605. https://doi.org/10.1016/j.phrs.2022.106605
  9. Penckofer, S., Kouba, J., Byrn, M., & Ferrans, C. E. (2010). Vitamin D and Depression: Where is all the Sunshine? Issues in Mental Health Nursing, 31(6), 385–393. https://doi.org/10.3109/01612840903437657
  10. WebMD Editorial Contributor. (2023, April 9). What to Know About Vitamin D and Mental Health. WebMD. https://www.webmd.com/vitamins-and-supplements/what-to-know-about-vitamin-d-and-mental-health
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